Title : Viperin interacts with the kinase IRAK1 and the E3 ubiquitin ligase TRAF6, coupling innate immune signaling to antiviral ribonucleotide synthesis.

Pub. Date : 2019 Apr 26

PMID : 30872404






1 Functional Relationships(s)
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1 We show that IRAK1 and TRAF6 increase viperin activity ~10-fold to efficiently catalyze the radical-mediated dehydration of CTP to ddhCTP. Cytidine Triphosphate radical S-adenosyl methionine domain containing 2 Homo sapiens