Title : Screening of novel 3α5β-neurosteroids for neuroprotective activity against glutamate- or NMDA-induced excitotoxicity.

Pub. Date : 2019 May

PMID : 30872014






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Pretreatment with neurosteroids significantly reduced acute L-glutamic acid or NMDA excitotoxicity mediated by Ca2+ entry and consequent ROS (reactive oxygen species) release and caspase-3 activation. Glutamic Acid caspase 3 Homo sapiens
2 This drop in Ca2+ level resulted in corresponding ROS suppression and prevented glutamate-induced caspase-3 activation. Glutamic Acid caspase 3 Homo sapiens