Title : DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo.

Pub. Date : 2018 Sep 14

PMID : 30868140






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that DREADD agonist 21 (C21) (11-(1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine) is a potent and selective agonist at both excitatory (hM3Dq) and inhibitory (hM4Di) DREADDs and has excellent bioavailability, pharmacokinetic properties, and brain penetrability. hm3dq TBL1X/Y related 1 Homo sapiens