Title : Inhibition of phosphodiesterase 4D decreases the malignant properties of DLD-1 colorectal cancer cells by repressing the AKT/mTOR/Myc signaling pathway.

Pub. Date : 2019 Mar

PMID : 30867802






5 Functional Relationships(s)
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Protein Name
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1 Previous studies reported that cyclic adenosine 3",5"-monophosphate (cAMP) can influence the AKT/mammalian target of rapamycin (mTOR) survival pathway in cancer and Myc is a critical downstream molecule of AKT/mTOR signaling. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens
2 Previous studies reported that cyclic adenosine 3",5"-monophosphate (cAMP) can influence the AKT/mammalian target of rapamycin (mTOR) survival pathway in cancer and Myc is a critical downstream molecule of AKT/mTOR signaling. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens
3 Previous studies reported that cyclic adenosine 3",5"-monophosphate (cAMP) can influence the AKT/mammalian target of rapamycin (mTOR) survival pathway in cancer and Myc is a critical downstream molecule of AKT/mTOR signaling. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens
4 Previous studies reported that cyclic adenosine 3",5"-monophosphate (cAMP) can influence the AKT/mammalian target of rapamycin (mTOR) survival pathway in cancer and Myc is a critical downstream molecule of AKT/mTOR signaling. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens
5 Notably, the current data imply that cAMP represses Myc expression via the downregulation of AKT/mTOR signaling, which was abolished by high PDE4D activities in DLD-1 cells. Cyclic AMP AKT serine/threonine kinase 1 Homo sapiens