Title : The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism.

Pub. Date : 2019 Mar 13

PMID : 30867454






2 Functional Relationships(s)
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Protein Name
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1 Cellular levels of 5fTHF are regulated by a futile cycle comprising the enzymes SHMT and 5,10-methenyltetrahydrofolate synthetase (MTHFS). Leucovorin methenyltetrahydrofolate synthetase Homo sapiens
2 Model simulations indicate that MTHFS plays an essential role in preventing 5fTHF accumulation, which consequently averts inhibition of all other reactions in the metabolic network. Leucovorin methenyltetrahydrofolate synthetase Homo sapiens