Title : Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer.

Pub. Date : 2019 Jun

PMID : 30862724






1 Functional Relationships(s)
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1 Mechanistically, Y42 phosphorylation occurs in IDH1 monomers, which promotes dimer formation with enhanced substrate (isocitrate or alpha-ketoglutarate) binding, whereas Y42-phosphorylated dimers show attenuated disruption to monomers. Ketoglutaric Acids isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens