Title : Nucleolar protein nucleolin functions in replication stress-induced DNA damage responses.

Pub. Date : 2019 May 1

PMID : 30839063






1 Functional Relationships(s)
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1 Furthermore, the knockdown of nucleolin by siRNA reduced the activation of ATM and RAD3-related (ATR) kinase and the formation of RAD51 and RPA32 foci after replication stress due to UV or camptothecin exposure, whereas nucleolin overexpression augmented ATR-dependent phosphorylation and RAD51 and RPA accumulation on chromatin. Camptothecin replication protein A2 Homo sapiens