Title : Infection by the parasitic helminth Trichinella spiralis activates a Tas2r-mediated signaling pathway in intestinal tuft cells.

Pub. Date : 2019 Mar 19

PMID : 30819885






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we show that both excretory-secretory products (E-S) and extract of T. spiralis can stimulate the release of the cytokine interleukin 25 (IL-25) from the mouse small intestinal villi and evoke calcium responses from tuft cells in the intestinal organoids, which can be blocked by a bitter-taste receptor inhibitor, allyl isothiocyanate. allyl isothiocyanate interleukin 25 Mus musculus