Title : CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability.

Pub. Date : 2019 Apr 1

PMID : 30819820






1 Functional Relationships(s)
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1 In particular, we found that phosphorylation of 4E-BP1 by mTORC1 (T37 and T46) facilitates subsequent CDK12 phosphorylation at two Ser-Pro sites (S65 and T70) that control the exchange of 4E-BP1 with eIF4G at the 5" cap of CHK1 and other target mRNAs. Serine CREB regulated transcription coactivator 1 Mus musculus