Title : Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2-p53 interaction.

Pub. Date : 2019 May

PMID : 30802707






1 Functional Relationships(s)
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1 Molecular modeling revealed that the compound 4d binds through hydrophobic-hydrophobic interactions with the essential amino acids (LEU: 57, GLY: 58, ILE: 61, and HIS: 96) in the p53-binding cleft, as a standard p53-MDM2 inhibitor (6SJ). Glycine tumor protein p53 Homo sapiens