Title : Prostaglandins as endogenous mediators of interleukin 1 production.

Pub. Date : 1986 Jan

PMID : 3079606






4 Functional Relationships(s)
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1 The addition of exogenous PGE2 or PGI2 resulted in a dose-dependent suppression of macrophage IL 1 production. Dinoprostone interleukin 1 complex Mus musculus
2 The addition of exogenous IL 1 to macrophage cultures caused an increase in the levels of PGE2, over a narrow dose range (0.05 to 0.6 IL 1 units). Dinoprostone interleukin 1 complex Mus musculus
3 The addition of exogenous IL 1 to macrophage cultures caused an increase in the levels of PGE2, over a narrow dose range (0.05 to 0.6 IL 1 units). Dinoprostone interleukin 1 complex Mus musculus
4 In addition, our data support the concept that IL 1, as with classical hormones, can regulate its own production through a self-induced inhibitor, PGE2. Dinoprostone interleukin 1 complex Mus musculus