Title : Quercetin Potentiates Docosahexaenoic Acid to Suppress Lipopolysaccharide-induced Oxidative/Inflammatory Responses, Alter Lipid Peroxidation Products, and Enhance the Adaptive Stress Pathways in BV-2 Microglial Cells.

Pub. Date : 2019 Feb 21

PMID : 30795510






3 Functional Relationships(s)
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1 DHA and quercetin can individually suppress lipopolysaccharide (LPS)-induced oxidative/inflammatory responses and enhance the antioxidative stress pathway involving nuclear factor erythroid-2 related factor 2 (Nrf2). Quercetin nuclear factor, erythroid derived 2, like 2 Mus musculus
2 DHA and quercetin can individually suppress lipopolysaccharide (LPS)-induced oxidative/inflammatory responses and enhance the antioxidative stress pathway involving nuclear factor erythroid-2 related factor 2 (Nrf2). Quercetin nuclear factor, erythroid derived 2, like 2 Mus musculus
3 Results showed that low concentrations of quercetin (2.5 microM), in combination with DHA (10 microM), could more effectively enhance the expression of Nrf2 and heme oxygenase 1 (HO-1), and suppress LPS-induced nitric oxide, tumor necrosis factor-alpha, phospho-cytosolic phospholipase A2, reactive oxygen species, and 4-hydroxynonenal, as compared to the same levels of DHA or quercetin alone. Quercetin nuclear factor, erythroid derived 2, like 2 Mus musculus