Title : Thermodynamic analysis of remote substrate binding energy in 3α-hydroxysteroid dehydrogenase/carbonyl reductase catalysis.

Pub. Date : 2019 Apr 1

PMID : 30794798






2 Functional Relationships(s)
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1 3alpha-HSD/CR uses remote binding interactions to accelerate the reaction of androsterone with NAD+. NAD aldo-keto reductase family 1 member C4 Homo sapiens
2 Here, we examine the enthalpic and entropic components of the remote binding energy in the 3alpha-HSD/CR-catalyzed reaction of NAD+ with androsterone versus the substrate analogs, 2-decalol and cyclohexanol, by analyzing the temperature-dependent kinetic parameters through steady-state kinetics. NAD aldo-keto reductase family 1 member C4 Homo sapiens