Title : MicroRNA‑223 attenuates LPS‑induced inflammation in an acute lung injury model via the NLRP3 inflammasome and TLR4/NF‑κB signaling pathway via RHOB.

Pub. Date : 2019 Mar

PMID : 30747229






1 Functional Relationships(s)
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1 An in vitro model was used to analyze the effect of miR-223 downregulation on an ALI model, which increased inflammation, and induced the activation of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome and Toll-like receptor 4 (TLR4)/nuclear factor (NF)-kappaB signaling pathway via rho-related GTP-binding protein RhoB (RHOB). Guanosine Triphosphate NLR family pyrin domain containing 3 Homo sapiens