Title : HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells.

Pub. Date : 2019 Feb 8

PMID : 30743996






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Restoring wild type p53 activity either by transfection or by treatment with APR-246, a molecule which reactivates mutant p53, blocked lapatinib-induced senescence and caused increased cell death. Lapatinib tumor protein p53 Homo sapiens
2 Restoring wild type p53 activity either by transfection or by treatment with APR-246, a molecule which reactivates mutant p53, blocked lapatinib-induced senescence and caused increased cell death. Lapatinib tumor protein p53 Homo sapiens