Title : Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors.

Pub. Date : 2019 May 14

PMID : 30742936






2 Functional Relationships(s)
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1 CA1 hippocampal expression of alpha4betadelta GABAA receptors (GABARs) increases at the onset of puberty in female mice, an effect dependent upon the decline in hippocampal levels of the neurosteroid THP (3alpha-OH-5alpha-pregnan-20-one) which occurs at this time. pirarubicin carbonic anhydrase 1 Mus musculus
2 These results suggest that both the rise in circulating levels of E2 and the decline in hippocampal THP levels at the onset of puberty trigger maximal levels of alpha4betadelta expression in the CA1 hippocampus. pirarubicin carbonic anhydrase 1 Mus musculus