Pub. Date : 2019 Feb 19
PMID : 30728297
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using atomic-level simulations of diverse GPCRs, we show that most of the water molecules in GPCR crystal structures are highly mobile. | Water | vomeronasal 1 receptor 17 pseudogene | Homo sapiens |
| 2 | Comparative analysis of GPCR crystal structures independently confirms the striking conservation of water-mediated interaction networks. | Water | vomeronasal 1 receptor 17 pseudogene | Homo sapiens |
| 3 | These conserved water-mediated interactions near the G protein-coupling region, along with diverse water-mediated interactions with extracellular ligands, have direct implications for structure-based drug design and GPCR engineering. | Water | vomeronasal 1 receptor 17 pseudogene | Homo sapiens |
| 4 | These conserved water-mediated interactions near the G protein-coupling region, along with diverse water-mediated interactions with extracellular ligands, have direct implications for structure-based drug design and GPCR engineering. | Water | vomeronasal 1 receptor 17 pseudogene | Homo sapiens |