Pub. Date : 2019 Feb 6
PMID : 30728290
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | We show by coimmunoprecipitation and mass spectrometry that the redox-regulated pyruvate kinase muscle 2 (PKM2) directly binds with p53 and that the redox status of cysteine-423 of tetrameric (but not monomeric) PKM2 is critical for the differential regulation of p53 transcriptional activity. | Cysteine | tumor protein p53 | Homo sapiens |
2 | We show by coimmunoprecipitation and mass spectrometry that the redox-regulated pyruvate kinase muscle 2 (PKM2) directly binds with p53 and that the redox status of cysteine-423 of tetrameric (but not monomeric) PKM2 is critical for the differential regulation of p53 transcriptional activity. | Cysteine | tumor protein p53 | Homo sapiens |