Pub. Date : 2019 May
PMID : 30725256
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | A potent, non-toxic benzodiazepine ("KRM-II-08") binds to the alpha5-GABAAR (0.8 microM EC50) enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, cytoplasmic localization. | krm-ii-08 | tumor protein p53 | Homo sapiens |
2 | A potent, non-toxic benzodiazepine ("KRM-II-08") binds to the alpha5-GABAAR (0.8 microM EC50) enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, cytoplasmic localization. | krm-ii-08 | tumor protein p53 | Homo sapiens |