Title : Modulating native GABAA receptors in medulloblastoma with positive allosteric benzodiazepine-derivatives induces cell death.

Pub. Date : 2019 May

PMID : 30725256






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 A potent, non-toxic benzodiazepine ("KRM-II-08") binds to the alpha5-GABAAR (0.8 microM EC50) enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, cytoplasmic localization. krm-ii-08 tumor protein p53 Homo sapiens
2 A potent, non-toxic benzodiazepine ("KRM-II-08") binds to the alpha5-GABAAR (0.8 microM EC50) enhancing a chloride-anion efflux that induces mitochondrial membrane depolarization and in response, TP53 upregulation and p53, constitutively phosphorylated at S392, cytoplasmic localization. krm-ii-08 tumor protein p53 Homo sapiens