Title : Ser46 phosphorylation of p53 is an essential event in prolyl-isomerase Pin1-mediated p53-independent apoptosis in response to heat stress.

Pub. Date : 2019 Feb 4

PMID : 30718466






5 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Our preliminary study revealed heat stress (HS)-induced apoptosis of vascular endothelial cells was associated with reactive oxygen species (ROS)-induced p53 translocation into mitochondria. Reactive Oxygen Species tumor protein p53 Homo sapiens
2 Our preliminary study revealed heat stress (HS)-induced apoptosis of vascular endothelial cells was associated with reactive oxygen species (ROS)-induced p53 translocation into mitochondria. Reactive Oxygen Species tumor protein p53 Homo sapiens
3 Based on these studies, we presumed Pin1 is a key intermediate in regulation of mitochondrial p53 translocation through a HS-induced ROS-p53 transcription-independent apoptosis pathway. Reactive Oxygen Species tumor protein p53 Homo sapiens
4 Based on these studies, we presumed Pin1 is a key intermediate in regulation of mitochondrial p53 translocation through a HS-induced ROS-p53 transcription-independent apoptosis pathway. Reactive Oxygen Species tumor protein p53 Homo sapiens
5 Furthermore, we also found ROS production was a critical mediator in HS-induced Pin1/p53 signaling and was involved in regulating mitochondrial apoptosis pathway activation. Reactive Oxygen Species tumor protein p53 Homo sapiens