Title : Metformin and tenovin-6 synergistically induces apoptosis through LKB1-independent SIRT1 down-regulation in non-small cell lung cancer cells.

Pub. Date : 2019 Apr

PMID : 30710424






1 Functional Relationships(s)
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1 The marked reduction in SIRT1 expression by combination of metformin and tenovin-6 increased acetylation of p53 at lysine 382 and enhanced p53 stability in LKB1-deficient A549 cells. Lysine tumor protein p53 Homo sapiens