Pub. Date : 2019 Apr
PMID : 30707421
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | One potential antifungal drug, FK506, establishes a ternary complex between the phosphatase, calcineurin, and the 12-kDa peptidyl-prolyl isomerase FK506-binding protein, FKBP12. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 2 | It has been well established that calcineurin, highly conserved from yeast to mammals, is necessary for invasive fungal disease and is inhibited when in complex with FK506/FKBP12. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 3 | Here we report the backbone and sidechain NMR assignments of recombinant FKBP12 proteins from the pathogenic fungi Mucor circinelloides and Aspergillus fumigatus in the apo form and compare these to the backbone assignments of the FK506 bound form. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 4 | In addition, we report the backbone assignments of the apo and FK506 bound forms of the Homo sapiens FKBP12 protein for evaluation against the fungal forms. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |
| 5 | These data are the first steps towards defining, at a residue specific level, the impacts of FK506 binding to fungal and mammalian FKBP12 proteins. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 1 | Homo sapiens |