Title : Blockage of sphingosine-1-phosphate receptor 2 attenuates allergic asthma in mice.

Pub. Date : 2019 Apr

PMID : 30706444






3 Functional Relationships(s)
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1 KEY RESULTS: Eosinophil accumulation and elevated Th2 cytokine levels in bronchoalveolar lavage fluid and inflamed lung tissues were strongly inhibited by administration of JTE-013 before OVA sensitization, before OVA challenge, and before both events. JTE 013 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus
2 KEY RESULTS: Eosinophil accumulation and elevated Th2 cytokine levels in bronchoalveolar lavage fluid and inflamed lung tissues were strongly inhibited by administration of JTE-013 before OVA sensitization, before OVA challenge, and before both events. JTE 013 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus
3 LPS- and OVA-induced maturation of BMDCs was significantly blunted in dendritic cells from S1P2 -deficient mice and by treatment with JTE-013. JTE 013 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus