Title : [THE BRAIN LEPTIN SIGNALING SYSTEM AND ITS FUNCTIONAL STATE IN METABOLIC SYNDROME AND TYPE 2 DIABETES MELLITIS].

Pub. Date : 2016 Mar

PMID : 30695496






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 This leads to activation of tyrosine kinase JAK2, which phosphory- lates tyrosine-containing sites located in the cytoplasmic domain of the receptor, resulting in stimulation of activity of phosphatidylinositol-3-kinase, the transcription factors STAT3 and STAT5, phosphatase SHP2, and mitogen-activated protein kinase. Tyrosine Janus kinase 2 Homo sapiens