Title : Organometallic ruthenium anticancer complexes inhibit human peroxiredoxin I activity by binding to and inducing oxidation of its catalytic cysteine residue.

Pub. Date : 2019 Mar 20

PMID : 30693924






1 Functional Relationships(s)
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1 Herein, we demonstrate that Ru complexes [(eta6-arene)Ru(en)Cl]+ (en = ethylenediamine, arene = p-cymene (1), biphenyl (2) and 9,10-dihydrophenanthrene (3)) can inhibit the enzymatic activity of human peroxiredoxin I (Prx-I) in an order of 1 > 3 > 2. 4-cymene peroxiredoxin 1 Homo sapiens