Title : Hydroxycamptothecin Prevents Fibrotic Pathways in Fibroblasts In Vitro.

Pub. Date : 2019 May

PMID : 30690843






1 Functional Relationships(s)
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1 In terms of mechanism, we pretreated fibroblasts with the endoplasmic reticulum stress (ER) inhibitor salubrinal and RNA-dependent protein kinase-like ER kinase (PERK) short hairpin RNA, these treatments abolished the inhibitory effects of HCPT on fibrosis, thereby suggesting that HCPT"s inhibition of TGF-beta1-induced tendon fibrosis might be mediated by the PERK signaling pathway in vitro. hydroxycamptothecinum transforming growth factor beta 1 Homo sapiens