Title : Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-α-activated retinal pigment epithelial cells.

Pub. Date : 2019 Apr

PMID : 30685603






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Quercetin, rottlerin, SP600125 and U0126 attenuated TNF-alpha-stimulated c-Jun phosphorylation and AP-1-Luc activity. rottlerin tumor necrosis factor Homo sapiens
2 Pretreatment with quercetin, rottlerin, SP600125, or Bay 11-7082 attenuated TNF-alpha-induced NF-kappaB (p65) phosphorylation, translocation and RelA/p65-Luc activity. rottlerin tumor necrosis factor Homo sapiens
3 TNF-alpha significantly increased MMP-9 promoter activity and THP-1 cell adherence, and these effects were attenuated by pretreatment with quercetin, rottlerin, SP600125, U0126, tanshinone IIA or Bay 11-7082. rottlerin tumor necrosis factor Homo sapiens