Pub. Date : 2019 Mar 1
PMID : 30684529
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hinokitiol suppresses growth of B16 melanoma by activating ERK/MKP3/proteosome pathway to downregulate survivin expression. | beta-thujaplicin | dual specificity phosphatase 6 | Homo sapiens |
| 2 | Hinokitiol rapidly induced ERK phosphorylation followed by a sustained dephosphorylation, which accompanied with an increase in expression of tumor suppressor MKP-3 (mitogen-activated protein kinase phosphatase-3). | beta-thujaplicin | dual specificity phosphatase 6 | Homo sapiens |
| 3 | Hinokitiol rapidly induced ERK phosphorylation followed by a sustained dephosphorylation, which accompanied with an increase in expression of tumor suppressor MKP-3 (mitogen-activated protein kinase phosphatase-3). | beta-thujaplicin | dual specificity phosphatase 6 | Homo sapiens |
| 4 | Inhibition of hinokitiol-induced ERK activation by MEK inhibitor U0126 completely blocked expression of MKP-3. | beta-thujaplicin | dual specificity phosphatase 6 | Homo sapiens |
| 5 | More importantly, inhibition of MKP-3 activity by NSC 95397 significantly inhibited hinokitiol-induced ERK dephosphorylation, ubiquitination and downregulation of survivin. | beta-thujaplicin | dual specificity phosphatase 6 | Homo sapiens |
| 6 | These results suggested that hinokitiol inhibited growth of B16-F10 melanoma through downregulation of survivin by activating ERK/MKP-3/proteosome pathway. | beta-thujaplicin | dual specificity phosphatase 6 | Homo sapiens |