Pub. Date : 2019 Apr 1
PMID : 30683654
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we show TGFbeta induces p38-mediated FH phosphorylation at Thr 90, which leads to a FH/CSL (also known as RBP-Jkappa)/p53 complex formation and FH accumulation at p21 promoter under concomitant activation of Notch signaling; in turn, FH inhibits histone H3 Lys 36 demethylation and thereby promotes p21 transcription and cell growth arrest. | Lysine | tumor protein p53 | Homo sapiens |