Title : Kappa opioid signaling in the central nucleus of the amygdala promotes disinhibition and aversiveness of chronic neuropathic pain.

Pub. Date : 2019 Apr

PMID : 30681985






2 Functional Relationships(s)
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1 After spinal nerve ligation (SNL) injury in rats, pretreatment with a long-acting KOR antagonist, nor-binaltorphimine (nor-BNI), subcutaneously or through microinjection into the right CeA, prevented conditioned place preference (CPP) to intravenous gabapentin, suggesting that nor-BNI eliminated the aversiveness of ongoing pain. norbinaltorphimine carcinoembryonic antigen gene family 4 Rattus norvegicus
2 Using whole-cell patch-clamp electrophysiology, we found that nor-BNI decreased synaptically evoked spiking of CeA neurons in brain slices from SNL but not sham rats. norbinaltorphimine carcinoembryonic antigen gene family 4 Rattus norvegicus