Title : Structural insights into the aggregation mechanism of huntingtin exon 1 protein fragment with different polyQ-lengths.

Pub. Date : 2019 Jun

PMID : 30672003






1 Functional Relationships(s)
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1 From our simulations, we suggest that at least 34 glutamines are required for initiating aggregation and 40 residues length is critical for the aggregation of huntingtin exon 1 protein for disease onset. Glutamine huntingtin Homo sapiens