Title : Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression‑independent manner in HPV‑positive human cervical cancer‑derived cells.

Pub. Date : 2019 Mar

PMID : 30664221






5 Functional Relationships(s)
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1 Quercetin induces G2 phase arrest and apoptosis with the activation of p53 in an E6 expression-independent manner in HPV-positive human cervical cancer-derived cells. Quercetin tumor protein p53 Homo sapiens
2 In the present study, it was demonstrated that quercetin induced G2 phase cell cycle arrest and apoptosis in both HeLa and SiHa cells, accompanied by an increase of p53 and its nuclear signal. Quercetin tumor protein p53 Homo sapiens
3 It was also observed that quercetin increased the level of the p21 transcript and the pro-apoptotic Bax protein, which are two p53-downstream effectors. Quercetin tumor protein p53 Homo sapiens
4 However, quercetin did not alter the expression of the HPV E6 protein in cervical cancer cells; therefore, the increase in p53 occurred in an E6 expression-independent manner. Quercetin tumor protein p53 Homo sapiens
5 These data suggest that quercetin increases the nuclear localization of p53 by interrupting E6/E6AP complex formation in cervical cancer cells. Quercetin tumor protein p53 Homo sapiens