Title : Glaucocalyxin A-induced oxidative stress inhibits the activation of STAT3 signaling pathway and suppresses osteosarcoma progression in vitro and in vivo.

Pub. Date : 2019 Jun 1

PMID : 30659925






2 Functional Relationships(s)
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1 Furthermore, we elucidate that the inhibition of STAT3 is mainly induced by ROS-mediated oxidative stress. Reactive Oxygen Species signal transducer and activator of transcription 3 Homo sapiens
2 Overall, our findings demonstrate that GLA could exhibit potent anticancer effects through effectively blocking the STAT3 signaling pathway, which was induced by ROS-mediated oxidative stress in OS in vitro and in vivo. Reactive Oxygen Species signal transducer and activator of transcription 3 Homo sapiens