Title : PIM inhibitor SMI-4a induces cell apoptosis in B-cell acute lymphocytic leukemia cells via the HO-1-mediated JAK2/STAT3 pathway.

Pub. Date : 2019 Feb 15

PMID : 30658101






1 Functional Relationships(s)
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1 Treatment with SMI-4a induced apoptosis by downregulating Bcl-2, upregulating Bax and other antiapoptotic proteins, and decreasing protein levels of p-JAK2 and p-STAT3. SMI-4a BCL2 associated X, apoptosis regulator Homo sapiens