Title : Communication between the Ligand-Binding Pocket and the Activation Function-2 Domain of Androgen Receptor Revealed by Molecular Dynamics Simulations.

Pub. Date : 2019 Feb 25

PMID : 30658039






2 Functional Relationships(s)
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1 As a result, the binding of the androgen DHT could promote the recruitment of the coactivator SRC3 to the AF2, and on the contrary, the binding of the antagonist HFT would induce a perturbation to the shape of the AF2 and then weaken its accommodating capability of the coactivators with the LXXLL motif. Dihydrotestosterone nuclear receptor coactivator 3 Homo sapiens
2 The simulation results illustrated that the DHT-AR binding affinity was enhanced by the association of the coactivator SRC3, which would reduce the conformational fluctuation of the AR-LBD and expand the size of the AR LBP. Dihydrotestosterone nuclear receptor coactivator 3 Homo sapiens