Title : Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.

Pub. Date : 2019 May

PMID : 30653446






1 Functional Relationships(s)
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1 Furthermore, GLI-family (transcription factors of the Hh pathway) knockdown in HUVECs and retinal vasculature revealed that downregulation of hyperglycemia-activated autophagy by the metformin-mediated Hh pathway activation was GLI1 dependent. Metformin GLI-Kruppel family member GLI1 Mus musculus