Title : Antagonism of IAPs Enhances CAR T-cell Efficacy.

Pub. Date : 2019 Feb

PMID : 30651288






1 Functional Relationships(s)
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1 Here, we demonstrated that antagonizing the "inhibitor of apoptosis proteins" with the clinical smac-mimetic, birinapant, significantly enhanced the antitumor activity of CAR T cells in a tumor necrosis factor (TNF)-dependent manner. birinapant nuclear receptor subfamily 1 group I member 3 Homo sapiens