Pub. Date : 2019 Mar
PMID : 30650200
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting mTORC1/2 with OSI-027 inhibits proliferation and migration of keloid keratinocytes. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Further, OSI-027 almost completely blocked the phosphorylation of the mTORC1 substrates, S6K1, S6 and 4EBP1, and the mTORC2 substrate, AKT, at Ser-473. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | The OSI-027 treatment of keloid keratinocytes showed more effectively inhibited cell proliferation and migration compared to the mTORC1 inhibitor, rapamycin. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Moreover, restoring mTORC1 activation by the introduction of the constitutively active S6K1 only partly alleviated OSI-027-induced inhibition of keloid keratinocytes. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | Together, our results imply that concurrent targeting of mTORC1/2 by OSI-027 potently inhibits the proliferation and the migration of keloid keratinocytes. | OSI 027 | CREB regulated transcription coactivator 1 | Mus musculus |