Title : Oxalomalate reduces tumor progression in melanoma via ROS-dependent proapoptotic and antiangiogenic effects.

Pub. Date : 2019 Mar

PMID : 30639360






1 Functional Relationships(s)
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1 Mechanistically, our findings showed that OMA activated p53-mediated apoptosis through ROS-dependent ATM-Chk2 signaling and reduced the expression of vascular endothelial growth factor through ROS-dependent E2F1-mediated hypoxia inducible factor-1alpha degradation. oxalomalic acid checkpoint kinase 2 Homo sapiens