Pub. Date : 2019 Jul
PMID : 30637517
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of BDNF-TrkB signaling has also been associated with the mechanism of action of ketamine and more recently with some other anesthetics, even with ones not thought to possess antidepressant potential. | Ketamine | neurotrophic receptor tyrosine kinase 2 | Homo sapiens |
| 2 | Notably, both ketamine and conventional antidepressants activate TrkB receptor and its downstream signaling rapidly within the same time scale in the brain while electroconvulsive therapy (ECT), among the most potent inducers of BDNF, has not been unequivocally shown to produce such acute effects on TrkB. | Ketamine | neurotrophic receptor tyrosine kinase 2 | Homo sapiens |
| 3 | Notably, both ketamine and conventional antidepressants activate TrkB receptor and its downstream signaling rapidly within the same time scale in the brain while electroconvulsive therapy (ECT), among the most potent inducers of BDNF, has not been unequivocally shown to produce such acute effects on TrkB. | Ketamine | neurotrophic receptor tyrosine kinase 2 | Homo sapiens |
| 4 | The purpose of this review is to highlight and discuss some of these peculiarities associated with the effects of ketamine and classical antidepressants and BDNF on TrkB signaling. | Ketamine | neurotrophic receptor tyrosine kinase 2 | Homo sapiens |