Pub. Date : 2019 Feb
PMID : 30636112
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | They have a pivotal role in iron-sulfur cluster biogenesis as regulators of the rates of cluster formation, as it is testified by the fact that frataxin absence is incompatible with life and reduced levels of the protein lead to the recessive neurodegenerative disease Friedreich"s ataxia. | Iron | frataxin | Homo sapiens |
| 2 | We also characterized the iron-binding mode of Ct frataxin and demonstrated that it binds it through a semiconserved negatively charged ridge on the first helix and beta-strand. | Iron | frataxin | Homo sapiens |
| 3 | Moreover, this frataxin is also able to bind the bacterial ortholog of the desulfurase, which is central in iron-sulfur cluster synthesis, and act as its inhibitor. | Iron | frataxin | Homo sapiens |