Pub. Date : 2019 Apr
PMID : 30630678
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Effect of Polymorphism in UGT1A4 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Patients With Breast Cancer in China. | Tamoxifen | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 2 | INTRODUCTION: UGT1A4 is a major enzyme responsible for the glucuronidation of tamoxifen (TAM) and its metabolites. | Tamoxifen | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 3 | INTRODUCTION: UGT1A4 is a major enzyme responsible for the glucuronidation of tamoxifen (TAM) and its metabolites. | Tamoxifen | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 4 | Genetic variations in the UGT1A4 gene could have a significant impact on the clinical efficacy of TAM. | Tamoxifen | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 5 | This study was performed to validate the association between UGT1A4 polymorphisms and the clinical outcomes for patients with breast cancer who received adjuvant TAM. | Tamoxifen | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |
| 6 | CONCLUSIONS: Our findings showed that patients with the UGT1A4 rs869283 G/A or A/A genotype received less benefit from adjuvant TAM treatment than those with the G/G genotype. | Tamoxifen | UDP glucuronosyltransferase family 1 member A4 | Homo sapiens |