Pub. Date : 2019 Mar 1
PMID : 30628485
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When macrophages were stimulated with LPS followed by ATP to activate the inflammasome, we found a significant increase in secreted IL-1beta from WT cells compared with ASK1-deficient cells. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 2 | Subsequent ATP treatment stimulated an increase in cleaved caspase-1 and IL-1beta in WT BMDMs compared with ASK1-/- BMDMs. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |
| 3 | Similarly, treatment of MH-S cells with LPS + ATP caused an increase in both cleaved caspase-1 and IL-1beta that was diminished by the ASK-1 inhibitor NQDI1. | Adenosine Triphosphate | interleukin 1 beta | Mus musculus |