Title : Metformin exhibited anticancer activity by lowering cellular cholesterol content in breast cancer cells.

Pub. Date : 2019

PMID : 30625181






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Similarly, metformin treatment suppressed expressions of anti-apoptotic genes BCL2 and Bcl-xL, and mesenchymal genes vimentin, N-cadherin, Zeb1 and Zeb2 with simultaneous enhancement of apoptotic caspase 3 and Bax, and epithelial genes E-cadherin and keratin 19 expressions, confirming an inhibitory effect of metformin in tumorigenesis. Metformin caspase 3 Homo sapiens