Title : Protective Role of Endogenous Kallistatin in Vascular Injury and Senescence by Inhibiting Oxidative Stress and Inflammation.

Pub. Date : 2018

PMID : 30622668






1 Functional Relationships(s)
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1 Kallistatin via its heparin-binding site antagonizes TNF-alpha-induced senescence and superoxide formation, while kallistatin"s active site is essential for inhibiting miR-34a synthesis, thus elevating sirtuin 1 (SIRT1)/eNOS synthesis in EPCs. Superoxides tumor necrosis factor Homo sapiens