Title : Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells.

Pub. Date : 2019 Jan 8

PMID : 30622244






2 Functional Relationships(s)
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1 In this study, we found that EPO suppresses p53-dependent apoptosis induced by genotoxic (daunorubicin, doxorubicin, and gamma-radiation) and non-genotoxic (nutlin-3a) agents and induces a senescence-like state in myeloid leukemia cells. Daunorubicin erythropoietin Homo sapiens
2 In addition, EPO antagonizes Mcl-1 protein degradation in daunorubicin-treated cells. Daunorubicin erythropoietin Homo sapiens