Title : Brain Distribution and Active Efflux of Three panRAF Inhibitors: Considerations in the Treatment of Melanoma Brain Metastases.

Pub. Date : 2019 Mar

PMID : 30622172






1 Functional Relationships(s)
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1 In vivo studies in mice show that the brain distribution of CCT196969, LY3009120, and MLN2480 is limited, and is enhanced in transgenic mice lacking P-gp and Bcrp. tak-580 phosphoglycolate phosphatase Mus musculus