Title : β3 -adrenergic receptor activation plays an important role in the depressed myocardial contractility via both elevated levels of cellular free Zn2+ and reactive nitrogen species.

Pub. Date : 2019 Aug

PMID : 30613975






1 Functional Relationships(s)
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1 Either beta3 -AR activation or its overexpression could increase cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS) levels, in line with significant changes in nitric oxide (NO)-pathway, including increases in the ratios of pNOS3/NOS3 and pGSK-3beta/GSK-3beta, and PKG expression level in cardiomyocytes. Reactive Nitrogen Species UDP glucuronosyltransferase family 1 member A8 Rattus norvegicus