Title : Role of Bone Marrow Mesenchymal Stromal Cells in Attenuating Inflammatory Reaction in Lipopolysaccaride-induced Acute Kidney Injury of Rats Associated with TLR4-NF-κB Signaling Pathway Inhibition.

Pub. Date : 2018 Nov

PMID : 30610044






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 This study was conducted to investigate whether BMSCs could alleviate the inflammation reaction in lipopolysaccaride (LPS)-induced acute kidney injury (septic-AKI) of rats via inhibition of toll-like receptors (TLR4)-nuclear factor-kappa B (NF-kappaB) signaling pathway. lps toll-like receptor 4 Rattus norvegicus
2 Results showed that LPS treatment caused the increases of the concentration of blood urea nitrogen (BUN) and serum creatinine (SCr), accompanied by tissue injury and the up-regulation of TLR4 and NF-kappaB, that was its key downstream signaling molecule, in both mRNA and protein level. lps toll-like receptor 4 Rattus norvegicus