Pub. Date : 2019 Feb
PMID : 30607648
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The pro-survival function of DLEC1 and its protection of cancer cells against 5-FU-induced apoptosis through up-regulation of BCL-XL. | Fluorouracil | DLEC1 cilia and flagella associated protein | Homo sapiens |
| 2 | DLEC1 overexpression promoted cell survival and reduced cell death in cancer cells after 5-FU treatment, while DLEC1 down-regulation sensitized cancer cells to 5-FU. | Fluorouracil | DLEC1 cilia and flagella associated protein | Homo sapiens |
| 3 | Our data also showed that BCL-XL was up-regulated by DLEC1 in stable clones after 5-FU treatment. | Fluorouracil | DLEC1 cilia and flagella associated protein | Homo sapiens |
| 4 | Altogether, these results indicated that DLEC1 protects cells against cell death induced by 5-FU through the attenuation of active proteins in caspase cascade and the up-regulation of BCL-XL. | Fluorouracil | DLEC1 cilia and flagella associated protein | Homo sapiens |
| 5 | Therefore, DLEC1 can be a pro-survival protein under certain circumstances and a potential therapeutic target for increasing sensitivity of cancer cells to 5-FU. | Fluorouracil | DLEC1 cilia and flagella associated protein | Homo sapiens |